PUBLICATIONS

Publications

2023 

• Hooshmandi M, Sharma V, Thorn Perez C, Sood R, Krimbacher K, Wong C, Lister K, Urena Guzman A, Bartley T, Rocha C, Maussion G, Nadler E, Roque P, Gantois I, Popic J, Levesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman R, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N, Gkogkas CG, and Khoutorsky A, Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron.
• Roque PS, Thörn Perez C, Hooshmandi M, Wong C, Eslamizade MJ, Heshmati S, Brown N, Sharma V, Lister KC, Goyon VM, Neagu-Lund L, Shen C, Daccache N, Sato H, Sato T, Mogil JS, Nader K, Gkogkas CG, Iordanova MD, Prager-Khoutorsky M, McBride HM, Lacaille JC, Wykes L, Schricker T, Khoutorsky A. Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice. Journal of Clinical Investigation.
• Yousefpour N, Locke S, Deamond H, Wang C, Marques L, St-Louis M, Ouellette J, Khoutorsky A, De Koninck Y, Ribeiro-da-Silva A. Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain. Cell Reports.

• Chalkiadaki K, Statoulla E, Zafeiri M, Haji N, Lacaille JC, Powell CM, Jafarnejad SM, Khoutorsky A (co-corresponding), Gkogkas CG. Reversal of memory and autism-related phenotypes in Tsc2^+/- mice via inhibition of Nlgn1, Front Cell Dev Biol

2022

• Tansley S, Gu N, Guzmán AU, Cai W, Wong C, Lister K, Muñoz-Pino E, Yousefpour N, Roome RB, Heal J, Wu N, Castonguay A, Lean G, Muir EM, Kania A, Prager-Khoutorsky M, Zhang J, Gkogkas CG, Fawcett JW, Diatchenko L, Ribeiro-da-Silva A, De Koninck Y, Mogil JS, Khoutorsky A. Microglia-mediated degradation of perineuronal nets promotes pain. Science.

• Chalkiadaki K, Hooshmandi M, Lach G, Statoulla E, Simbriger K, Amorim IS, Kouloulia S, Zafeiri M, Pothos P, Bonneil É, Gantois I, Popic J, Kim SH, Wong C, Cao R, Komiyama NH, Atlasi Y, Jafarnejad SM, Khoutorsky A (co-corresponding), Gkogkas CG. Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1. Brain.

• Wong C, Barkai O, Wang F, Thörn Pérez C, Lev S, Cai W, Tansley S, Yousefpour N, Hooshmandi M, Lister KC, Latif M, Cuello AC, Prager-Khoutorsky M, Mogil JS, Séguéla P, De Koninck Y, Ribeiro-da-Silva A, Binshtok AM, Khoutorsky A. mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation. Journal of Clinical Investigation.

• Tansley S, Uttam S, Ureña Guzmán A, Yaqubi M, Pacis A, Parisien M, Deamond H, Wong C, Rabau O, Brown N, Haglund L, Ouellet J, Santaguida C, Ribeiro-da-Silva A, Tahmasebi S, Prager-Khoutorsky M, Ragoussis J, Zhang J, Salter MW, Diatchenko L, Healy LM, Mogil JS, Khoutorsky A. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nature Communications.

• Toboz P, Amiri M, Tabatabaei N, Dufour CR, Kim SH, Fillebeen C, Ayemoba CE, Khoutorsky A, Nairz M, Shao L, Pajcini KV, Kim KW, Giguère V, Oliveira RL, Constante M, Santos MM, Morales CR, Pantopoulos K, Sonenberg N, Pinho S, Tahmasebi S. The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. PNAS.

• Farooq Z, Kusuma F, Burke P, Dufour CR, Lee D, Tabatabaei N, Toboz P, Radovani E, Greenblatt JF, Rehman J, Class J, Khoutorsky A, Fonseca BD, Richner JM, Mercier E, Bourque G, Giguère V, Subramaniam AR, Han J, Tahmasebi S. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1). J Biol Chem.

• Verma V, Drury GL, Parisien M, Özdağ Acarli AN, Al-Aubodah TA, Nijnik A, Wen X, Tugarinov N, Verner M, Klares R 3rd, Linton A, Krock E, Morado Urbina CE, Winsvold B, Fritsche LG, Fors EA, Piccirillo C, Khoutorsky A, Svensson CI, Fitzcharles MA, Ingelmo PM, Bernard NF, Dupuy FP, Üçeyler N, Sommer C, King IL, Meloto CB, Diatchenko L; HUNT-All In Pain. Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia. Pain.

2021

• Hooshmandi M, Truong VT, Fields E, Thomas RE, Wong C, Sharma V, Gantois I, Soriano Roque P, Chalkiadaki K, Wu N, Chakraborty A, Tahmasebi S, Prager-Khoutorsky M, Sonenberg N, Suvrathan A, Watt AJ, Gkogkas CG, Khoutorsky A. 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell Reports.

• Sharma V, Sood R, Lou D, Hung TY, Lévesque M, Han Y, Levett JY, Wang P, Murthy S, Tansley S, Wang S, Siddiqui N, Tahmasebi S, Rosenblum K, Avoli M, Lacaille JC, Sonenberg N, Khoutorsky A. 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. PNAS.

• Soriano Roque P, Hooshmandi M, Neagu-Lund L, Yin S, Yousefpour N, Sato H, Sato T, Nakadate Y, Kawakami A, Tahmasebi S, Ribeiro-da-Silva A, Gkogkas CG, Prager-Khoutorsky M, Schricker T, Wykes L, Khoutorsky A. Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Scientific Reports.

2020

• Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M, Kiniry SJ, Stokes MP, Cohen N, Nelson AJ, Abell K, Possemato AP, Gal-Ben-Ari S, Truong VT, Wang P, Yiannakas A, Saffarzadeh F, Cuello AC , Nader K, Kaufman RJ, Costa-Mattioli M , Baranov PV, Quintana A, Sanz E, Khoutorsky A*, Lacaille JC*, Rosenblum K*, Sonenberg N*. eIF2α controls memory consolidation via excitatory and somatostatin neurons. Nature. (* joint supervision).

• Simbriger K, Amorim IS, Lach G, Chalkiadaki K, Kouloulia S, Jafarnejad SM, Khoutorsky A  (co-corresponding), Gkogkas CG*. Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling. Progress in Neurobiology.

• Hooshmandi M, Wong C, Khoutorsky A. Dysregulation of translational control signaling in autism spectrum disorders. Cellular Signaling.

• Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A, Gkogkas CG. Monitoring translation in synaptic fractions using a ribosome profiling strategy. J Neurosci Methods.

2019

• Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A (co-corresponding), Gkogkas CG. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Reports.

• Wiebe S, Nagpal A, Truong VT, Park J, Skalecka A, He AJ, Gamache K, Khoutorsky A, Gantois I, Sonenberg N. Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2. PNAS.

• Parisien M, Samoshkin A, Tansley SN, Piltonen MH, Martin LJ, El-Hachem N, Dagostino C, Allegri M, Mogil JS, Khoutorsky A, Diatchenko L. Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain. PAIN.


• Megat S, Ray PR, Moy JK, Lou T, Barragan-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, and Price TJ. Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain. Journal of Neuroscience.

• Gantois I, Popic J, Khoutorsky A, Sonenberg N. Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders. Annual Reviews of Medicine. 

2018

• Khoutorsky A, Price TJ. Translational Control Mechanisms in Persistent Pain. Trends Neuroscience

• Uttam S, Wong C, Price TJ, Khoutorsky A. eIF4E-dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity. Front. Genet.

• Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N. Translation deregulation in human disease. Nat Rev Mol Cell Biol.

• Moy JK, Khoutorsky A, Asiedu MN, Dussor G, Price TJ. eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons. Front Cell Neuroscience.

• Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Translational control of ERK signaling through miRNA/4EHP-directed silencing. eLife.

• Uttam S, Wong C, Amorim IS, Jafarnej SM, Tansley SN, Yang J, Prager-Khoutorsky M, Mogil JS, Gkogkas CG, Khoutorsky A. Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of Pain.

• Tansley SN, Wong C, Uttam S, Mogil JS, Khoutorsky A. Translation regulation in the spinal dorsal horn – A key mechanism for development of chronic pain. Neurobiology of Pain.

2017

• Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Tiffany Cole, Thang M. Khuong, Ellen Mir, Dustin G. Gibson, Jeffrey S. Wieskopf, Sotocinal SG, Austin JS, Meloto CB, Gitt JH, Gkogkas C, Sonenberg N, Greenspan JD, Fillingim RB, Ohrbach R, Slade GD, Knott C, Dubner R, Nackley AG, Ribeiro-da-Silva A, Neely GG, Maixner W, Zaykin DV, Mogil JS, Diatchenko L. Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest. 


• Moy JK, Khoutorsky A, Asiedu MN, Black BJ,Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio KK, Mogil JS, Dussor G, Sonenberg N, Price TJ. The MNK — eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain. J Neuroscience.


• Gantois I*, Khoutorsky A*, Popic J*, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature Medicine. (* equal contribution).


• Tuttle AH, Tansley S, Dossett K, Tohyama S, Khoutorsky A, Maldonado-Bouchard S, Stein L, Gerstein L, Crawhall-Duk H, Pearl R, Sukosd M, Leger P, Hardt OM, Yachnin D, Austin JS, Chan CM, Pooters T, Groves I, Martin LJ, Sonenberg N, Gkogkas CG, Mogil JS. Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes. PNAS.

2016

• Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. PNAS.


• Khoutorsky A*, Sorge RE*, Prager-Khoutorsky M*, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N. Cellular stress response pathway controls thermal nociception via translational regulation of TRPV1. PNAS. (* equal contribution).


• Skałecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J. mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Developmental Neurobiology.

2015

• Khoutorsky A*, Bonin RP*, Sorge RE*, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N. Translational control of nociception via 4E-binding protein 1. eLife. (* equal contribution).


• Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. J. Neuroscience.


• Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE. mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress. Molecular Cancer Research. 


• Melemedjian OK, Khoutorsky A. Translational control of chronic pain. In book: Prog Mol Biol Transl Sci.

2014

• Gkogkas CG*, Khoutorsky A*, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. Cell Reports. (* equal contribution).


• Prager-Khoutorsky M, Khoutorsky A, Bourque CW. Unique interweaved microtubule scaffold mediates osmosensory transduction via physical interaction with TRPV1. Neuron.


• Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, Kim K, Yang XJ, Sonenberg N. Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell.


• Gkogkas C, Aguilar-Valles A, Khoutorsky A, and Sonenberg N. (2014). Translational control of autism and Fragile-X syndrome. In book: Frontiers in Autism Research, Publisher: World Scientific, Editors: Valerie W Hu, pp.249-276

2013

• Graber TE, Hébert-Seropian S, Khoutorsky A, David A, Yewdell JW, Lacaille JC, Sossin WS. Reactivation of stalled polyribosomes in synaptic plasticity. PNAS


• Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N. Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron.


• Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. eLife.


• Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N. Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. PloS Biology.


• Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R, Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron. * Recommended by Faculty of 1000.


• Melemedjian OK*, Khoutorsky A*, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. (* equal contribution).


• Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V. Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver. Cell Metabolism.


• Ran I, Gkogkas CG, Vasuta C, Tartas M, Khoutorsky A, Laplante I, Parsyan A, Nevarko T, Sonenberg N, Lacaille JC. Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. J Neuroscience.


• Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 


• Khoutorsky A., Gkogkas, C., and Sonenberg N. Translational Control of Synaptic Plasticity and Memory. In book: Biophysics for the Life Sciences Vol I, 2013: Biophysical approaches to translational control of gene expression. Springer, XII, Pages 289-310


• Sorge RE, LaCroix-Fralish ML, Tuttle AH, Khoutorsky A, Sotocinal SG, Austin JS, Melmed K, Labialle S, Schmidt JV, Wood JN, Naumova AK, Mogil JS. The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene. Genes Brain Behav. 

2005-2012

• Melemedjian OK, Asiedu MN, Tillu DV, Sanoja R, Yan J, Lark A, Khoutorsky A, Johnson J, Peebles KA, Lepow T, Sonenberg N, Dussor G, Price TJ. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Molecular Pain. 2011 Sep 21;7:70.


• Khoutorsky A, Heyman A, Shoseyov O, Spira ME. Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1. Nano Letter. 2011 Jul 13;11(7):2901-4.


• Khoutorsky A, Spira ME. Activity-dependent calpain activation plays a critical role in synaptic facilitation and post-tetanic potentiation. Learning and Memory. 2009 Jan 29;16(2):129-41.


• Khoutorsky A, Spira ME. Calpain inhibitors alter the excitable membrane properties of cultured aplysia neurons. J Neurophysiol. 2008 Nov;100(5):2784-93.


• Sahly I*, Khoutorsky A*, Erez H, Prager-Khoutorsky M, Spira ME. On-line confocal imaging of the events leading to structural dedifferentiation of an axonal segment into a growth cone after axotomy. J Comp Neurol. 2006 Feb 10;494(5):705-20, (* equal contribution).


• Khoutorsky A, Spira ME. Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia. Learning and Memory. 2005 Jul-Aug;12(4):414-22.